A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice.
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molecules-25-03730.pdf
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Resource type
Journal article
Date published
August 15, 2020
Abstract
Tricin, a flavone isolated from rice bran, has been shown to be chemopreventive in a colorectal cancer (CRC) mouse model. This study aimed to illustrate the inhibitory activities of tricin in colon cancer cells and in a metastatic CRC mouse model. BALB/c mice injected with mouse Colon26-Luc cells into the rectum wall were treated with tricin (37.5 mg/kg) daily for 18 days. Orthotopic colon tumor growth and metastasis to lungs were assessed by in vivo bioluminescence imaging. Results showed that tricin suppressed Colon-Luc cells motility and downregulated phosphorylated Akt, Erk1/2 and NF-κB expressions of human colon cancer HT-29 cells. While tricin treatment suppressed tumor growth and lung metastasis as well as altered the populations of myeloid-derived suppressor cells and regulatory T cells in spleens. In summary, the tumor microenvironment modulatory and anti-metastatic effects of tricin in colon cancer mouse model were shown for the first time, suggesting the potential development of tricin-containing food supplements for CRC patients.
Funder
| Funder name | Awards |
Chinese University of Hong Kong, Hong Kong | Impact Postdoctoral Fellowship Scheme - Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine |
Institute of Chinese Medicine | |
State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants | |
Journal title
Molecules
Volume
25
Issue
16
Article number
3730
Publisher
MDPI AG
Place of publication
Basel, Switzerland
eISSN
1420-3049
Date accepted
August 13, 2020
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Additional information
This article belongs to the Section Medicinal Chemistry.