Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

Salim, Fatimah; Yunus, Yusri Mohd; Anouar, El Hassane; Awang, Khalijah; Langat, Moses; Cordell, Geoffrey A.; Ahmad, Rohaya

Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

Resource type

Journal article

Creator (person)

Salim, Fatimah

ORCID

Yunus, Yusri Mohd

Anouar, El Hassane

ORCID

Awang, Khalijah

Langat, Moses

Cordell, Geoffrey A.

Ahmad, Rohaya

Date published

November 5, 2019

Abstract

The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method.