Coumarinolignoid and Indole Alkaloids from the Roots of the Hybrid Plant Citrus x paradisi Macfad. (Rutaceae).
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molecules-28-01078__1_.pdf
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342.69 KB
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Resource type
Journal article
Date published
January 20, 2023
Abstract
A phytochemical investigation of the roots of Citrus x paradisi Macfad. (Rutaceae) led to the isolation of two new compounds, namely 1-formyl-5-hydroxy-N-methylindolin-1-ium (1) and decyloxycleomiscosin D (2), along with ten known compounds: 1,1-dimethylpyrrolidin-1-ium-2-carboxylate (3), furan-2,3-diol (4), 5-methoxyseselin (5), umbelliferone (6), scopoletin (7), citracridone I (8), citracridone II (9), citracridone III (10), limonin (11) and lupeol (12). The structures were determined through the comprehensive spectroscopic analysis of 1D and 2D NMR and EI- and ESI-MS, as well as a comparison with the published data. Notably, compounds 3 and 4 from the genus Citrus are reported here for the first time. In addition, the MeOH extract of the roots and compounds 1–7 were screened against the human adenocarcinoma alveolar basal epithelial cell line A549 and the Caucasian prostate adenocarcinoma cell line PC3 using the MTT assay. While the extract showed significant activity, with IC50 values of 35.2 and 38.1 µg/mL, respectively, compounds 1–7 showed weak activity, with IC50 values of 99.2 to 250.2 µM and 99.5 to 192.7 µM, respectively.
Project(s)
Priority 2: Trait Diversity and Function
Funder
| Funder name | Awards |
Royal Society of Chemistry, United Kingdom | IES/R1/180061 |
Alexander von Humboldt-Stiftung, Germany | Renewed Research Stay 2021 |
Deutscher Akademischer Austauschdienst, Germany | YaBiNaPA |
Deutsche Forschungsgemeinschaft | Open Access Publication Fund of Bielefeld University |
Journal title
Molecules
Volume
28
Issue
3
Article number
1078
Publisher
MDPI AG
Place of publication
Basel, Switzerland
eISSN
1420-3049
Date accepted
January 16, 2023
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In Copyright
Additional information
IF = 4.148 (2022-2023)