Lipid metabolism is dysregulated in a mouse model of diabetes.
Name
s11306-022-01884-w.pdf
Description
visibility:open
Size
671.98 KB
Format
Adobe PDF
Checksum (CRC64NVME)
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Resource type
Journal article
Creator (person)
Furse, Samuel
Date published
June 2022
Abstract
Much evidence for diabetes mellitus being associated with dysregulated lipid metabolism has been accrued from studies using blood plasma. However, the systemic dysregulation these results point to is not understood. This study used Lipid Traffic Analysis on data from a mouse model of diabetes to test the hypothesis that the systemic control of lipid metabolism differed in a model of diabetes. This provided eidence for changes in the systemic control of both triglyceride and phospholipid metabolism that were not attributable to dietary intake. This supports the conclusion that diabetes is a systemic condition associated with dysregulated lipid metabolism through several pathways.
Project(s)
Priority 2: Trait Diversity and Function
Funder
| Funder name | Awards |
Biotechnology and Biological Sciences Research Council, United Kingdom | BB/M027252/1 - BB/T014210/1 |
Journal title
Metabolomics
Volume
18
Article number
36
Publisher
Springer Science and Business Media LLC
Place of publication
Berlin/Heidelberg, Germany
eISSN
1573-3890
Date accepted
April 1, 2022
Official URL
Rights statement
In Copyright
Additional information
IF = 4.29 (2021-2022)