New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm).
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fphar-12-760674.pdf
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Resource type
Journal article
Date published
October 14, 2021
Abstract
L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the and models of epilepsy to probe the anticonvulsant potentials of essential oil from (MO) to gain insight into the scientific basis for its applications in traditional medicine for the management of convulsive disorders. MO was evaluated for effects on maximal electroshock (MES) and pentylenetetrazole (PTZ) -induced seizures in mice, on 4–aminopyridine (4-AP)-brain slice model of epilepsy and sustained repetitive firing of current clamped neurons; and its ameliorative effects were examined on seizure severity, anxiety, depression, cognitive dysfunction, oxidative stress and neuronal cell loss in PTZ-kindled rats. MO reversibly blocked spontaneous ictal-like discharges in the 4-AP-brain slice model of epilepsy and secondary spikes from sustained repetitive firing, suggesting anticonvulsant effects and voltage-gated sodium channel blockade. MO protected mice from PTZ– and MES–induced seizures and mortality, and ameliorated seizure severity, fear-avoidance, depressive-like behavior, cognitive deficits, oxidative stress and neuronal cell loss in PTZ–kindled rats. The findings warrant further study for the potential use of MO and/or its constituent(s) as adjunctive therapy for epileptic patients.
Funder
| Funder name | Awards |
Alzheimer’s Research, United Kingdom | |
Make My Day Better | |
Kaduna State University, Nigeria | |
Journal title
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Place of publication
[Lausanne, Switzerland]
eISSN
1663-9812
Date accepted
September 27, 2021
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In Copyright
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IF: 5.810