Secoisopimaranes from Salvia elegans Vahl leaves as antibacterial agents against Staphylococcus aureus.
Name
s41598-025-19109-0.pdf
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1.43 MB
Format
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Resource type
Journal article
Date published
October 8, 2025
Abstract
The genus Salvia contains around 1000 species and is primarily known to produce caffeic acid polymers and diterpenes. Of the bi- and tricyclic classes of diterpenes found in Salvia, isopimaranes are the least represented. The bio-guided metabolomic analysis of the leaves of Salvia elegans Vahl revealed the occurrences of three secoisopimaranes ( – ), of which the known 3,4-secoisopimara-7,15-dien-3-oic acid was the most abundant and showed potent antimicrobial activity against Staphylococcus aureus with a MIC = 15.6 µg/mL (51.6 µM). All three diterpenes were detected in domesticated and wild specimens of the closely related species Salvia cinnabarina M.Martens & Galeotti, but not in other species reportedly to be closely related to S. elegans. Diterpenoids from are an interesting group of biologically active molecules and their distribution within the genus justifies further study.
Project(s)
Priority 5: Enhanced Partnerships
Funder
| Funder name | Awards |
Procter and Gamble, United States | Academic grant |
Journal title
Scientific Reports
Volume
15
Article number
35200
Publisher
Springer Science and Business Media LLC
Place of publication
Berlin/Heidelberg, Germany
eISSN
2045-2322
Date accepted
September 5, 2025
Official URL
Rights statement
In Copyright
Additional information
IF = 3.9 (2024)