Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae).

Chemical investigation of the roots of yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3 ,4 ,6 -triol ( ), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives ( ) and ( + ) were obtained by hemi-synthetic reaction of compound . The structures of – were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound and + were determined to show significant activities against MIC values of 6.25 μg mL while compound displayed weak activity showing MIC > 100 μg mL . Compounds – displayed moderate activity with MIC values range from 12.5 to 50 μg mL .