Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice.
Name
journal.pone.0313205.pdf
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visibility:open
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1.52 MB
Format
Adobe PDF
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Resource type
Journal article
Date published
November 7, 2024
Abstract
Environmental exposure to cold is increasingly being associated with changes in metabolism. We developed and tested the hypothesis that exposure to cold drives systemic effects in lipid metabolism. Specifically, (i) that energy storage and provision adapts to the cold by altering triglyceride distribution and (ii) that membranes adapt to cold conditions by becoming more unsaturated. These hypotheses were designed to identify the underlying mechanisms that govern the response of mammalian systems to cold. To test these hypotheses, we used a metabolic network analysis. An established model of cold exposure was used, from which lipidomics data that represents the system was collected. The network analysis showed that triglyceride metabolism is altered on exposure to cold, with several smaller effects that are not straightforward, such as changes to the abundance and distribution of odd chain fatty acids. The range and profile of phosphatidylcholine and phosphatidylinositol were modified, but there was little cha
Contributor (person)
Witt, Stephan N.
Project(s)
Priority 2: Trait Diversity and Function
Funder
| Funder name | Awards |
Biotechnology and Biological Sciences Research Council, United Kingdom | BB/M027252/1 - BB/T014210/1 |
University of Wisconsin-Madison, United States | Start-up funds |
Journal title
PLOS ONE
Volume
19
Issue
11
Article number
e0313205
Publisher
Public Library of Science (PLoS)
Place of publication
San Francisco, Calif., US
eISSN
1932-6203
Date accepted
October 15, 2024
Official URL
Rights statement
In Copyright
Additional information
IF = 3.7 (2023-2024)