First report of compounds from an Ancistrocarpus species: Triterpenoids from A. densispinosus Oliv. (Malvaceae)

Peyeino, Jules H.; Djomkam, Hermine L. Maza; Kenmogne, Sidonie Beatrice; Langat, Moses Kiprotich; Isyaka, Sani Mohammed; Tsopgni, Willifred Dongmo Tekapi; Wansi, Jean Duplex; Kamdem Waffo, Alain Francois; Sewald, Nobert; Vardamides, Juliette Catherine

First report of compounds from an Ancistrocarpus species: Triterpenoids from A. densispinosus Oliv. (Malvaceae)

Resource type

Journal article

Creator (person)

Peyeino, Jules H.

Djomkam, Hermine L. Maza

Kenmogne, Sidonie Beatrice

Langat, Moses Kiprotich

Isyaka, Sani Mohammed

Tsopgni, Willifred Dongmo Tekapi

Wansi, Jean Duplex

Kamdem Waffo, Alain Francois

Sewald, Nobert

Vardamides, Juliette Catherine

Date published

June 29, 2020

Abstract

The stem bark of Ancistrocarpus densispinosus Oliv. exhibited triterpenoids, including the rare fernane-type, fern-9(11)-ene-2α,3β-diol (1) a possible chemotaxonomically distinct biomolecule for the genus. Other triterpenoids that were isolated from this plant include the ursane-type ursolic acid (2) and corosolic acid (3), friedelane-type friedelin (4) and canophyllol (5), lupane-type lupeol (6), betulin (7), betulinic acid (8) and hennadiol (9), oleanoic acid (10), maslinic acid (11) and taraxerol (12) and three sterols. This is the first report of the chemistry of a plant of the Ancistrocarpus. The structures of the compounds were elucidated based on their NMR, IR and MS techniques and by comparisons of their experimental data with those reported. The twelve triterpenoids 1–12 were found to be inactive against five bacterial strains Escherichia coli, Bacillus subtilis, Pseudomonas agarici, Micrococcus luteus and Staphylococcus warneri; inactive against KB-3-1 cervix carcinoma cancer cell line and inactive as antioxidants in the DPPH assay.