The chemical constituents of Penianthus longifolius Miers
Resource type
Journal article
Creator (person)
Tabekoueng, Georges
Akak, Carine
Langat, Moses K.
Blaise, Azebaze
Kamdem Waffo, Alain
Mulholland, Dulcie
Vardamides, Juliette
Date published
February 6, 2019
Abstract
Fourteen compounds were isolated from the roots, leaves and twigs of Penianthus longifolius Miers (Menispermaceae), including two previously unreported neo-clerodane diterpenoids, penianthin (1), its C-8 epimer (2). In addition, the previously reported O-methylmoschatoline (3), taraxerol (4), taraxerone (5), rubrosterone, (6), panuosterone (7), 22-epi-20-hydroxyecdysone (8), ergosterol peroxide (9), stigmast-5-ene-3,7-dione (10), stigmasterol (11), β-sitosterol (12), stigmasterol glucoside (13) and β-sitosterol glucoside (14) were isolated. The structures of the compounds were determined by means of NMR spectroscopic and mass spectrometric analysis. The absolute configurations of 1 and 2 were determined by circular dichroism analysis. Compounds 1 and 2 were screened against the NCI60 cancer cell panel but showed no significant activity at 10 μM.
Journal title
Phytochemistry Letters
Volume
30
ISSN
1874-3900
Rights statement
In Copyright