Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert

Langat, Moses K.; Ndunda, Beth M.; Salter, Caitlin; Odusina, Babatope O.; Isyaka, Sani M.; Mas-Claret, Eduard; Onocha, Patricia A.; Midiwo, Jacob O.; Nuzillard, Jean-Marc; Mulholland, Dulcie A.

Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert

Resource type

Journal article

Creator (person)

Langat, Moses K.

Ndunda, Beth M.

Salter, Caitlin

Odusina, Babatope O.

Isyaka, Sani M.

Mas-Claret, Eduard

Onocha, Patricia A.

Midiwo, Jacob O.

Nuzillard, Jean-Marc

Mulholland, Dulcie A.

Date published

October 2020

Abstract

Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR, IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 that were selected for screening based on their ability to add diversity to the NCI small molecule compound collection, were evaluated against the NCI60 panel of human tumour cell lines at 10μM level but found to be inactive.