Melanin Production Inhibitors from the West African Cassipourea congoensis
Name
a-1006-2880.pdf
Description
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Size
955.43 KB
Format
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Resource type
Journal article
Creator (person)
Takou, Dieudonné M.
Waffo, Alain F. Kamdem
Langat, Moses K.
Wansi, Jean D.
Mulcahy-Ryan, Lauren E.
Schwikkard, Sianne L.
Opara, Elizabeth I.
Mas-Claret, Eduard
Mulholland, Dulcie A.
Date published
October 1, 2019
Abstract
Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid 1 and 24-methylenecycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6, (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 µM with low cytotoxicity validating the ethnomedicinal use of this plant.
Journal title
Planta Medica International Open
Volume
6
Issue
02
Publisher
Georg Thieme Verlag KG
ISSN
2509-9264
eISSN
2509-6656
Rights statement
In Copyright