Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert.

Resource type
Journal article
Creator (person)
Langat, Moses K.
Ndunda, Beth M.
Salter, Caitlin
Odusina, Babatope O.
Isyaka, Sani M.
Mas-Claret, Eduard
Onocha, Patricia A.
Midiwo, Jacob O.
Nuzillard, Jean-Marc
Mulholland, Dulcie A.
Date published
October 2020
Abstract
Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR, IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 that were selected for screening based on their ability to add diversity to the NCI small molecule compound collection, were evaluated against the NCI60 panel of human tumour cell lines at 10μM level but found to be inactive.
Funder
Funder nameAwards
University of Nairobi, Kenya
International Foundation for Science, Sweden
International Science Program, Sweden
Organisation for the Prohibition of Chemical Weapons, Netherlands
Natural Products Research Network for East and Central Africa
Journal title
Phytochemistry Letters
Volume
39
Publisher
Elsevier BV
Place of publication
Amsterdam, Netherlands
ISSN
1874-3900
eISSN
1876-7486
Date accepted
July 3, 2020
Official URL
Rights statement
In Copyright
DOI
Keywords