The chemistry and biological activities of Citrus clementina Hort. Ex Tanaka (Rutaceae), a vegetatively propagated species

Bissim, Samuel Magloire; Kenmogne, Sidonie Beatrice; Lobe, Jules Songue; Atangana, Albert Fouda; Bissoue, Achile Nouga; Langat, Moses K.; Isyaka, Sani M.; Lateef, Mehreen; Emmanuel, Ngeufa Happi; Wansi, Jean Duplex; Ali, Muhammad Shaiq; Waffo, Alain François Kamdem

The chemistry and biological activities of Citrus clementina Hort. Ex Tanaka (Rutaceae), a vegetatively propagated species

Resource type

Journal article

Creator (person)

Bissim, Samuel Magloire

Kenmogne, Sidonie Beatrice

Lobe, Jules Songue

Atangana, Albert Fouda

Bissoue, Achile Nouga

Langat, Moses K.

Isyaka, Sani M.

Lateef, Mehreen

Emmanuel, Ngeufa Happi

Wansi, Jean Duplex

Ali, Muhammad Shaiq

Waffo, Alain François Kamdem

Date published

February 24, 2020

Abstract

We report the chemistry and biological activities of a Cameroonian Citrus clementina Hort. Ex Tanaka, a vegetatively propagated species. The compounds isolated from this plant were determined to be the known 5-hydroxy-6,7,8,3’,4’-pentamethoxyflavone (1), tangerine (3), nobilletin (4), 5,7,8,4’-tetramethoxyflavone (5), citracridone I (6), 5-hydroxynoracronycine (7), citracridone III (8), xanthyletin (10), suberosin (9), E-suberenol (11), E-methoxysuberenol (13), 6-formylumbelliferone (12), aurantiamide acetate (2), limonin (14), stigmasterol, β-sitosterol and β-sitosterol-3-O-β-D-glucoside. The structures of the compounds were established on the basis of their NMR spectroscopic data and comparison with published data. Methanol leaf extract and compounds 1, 2, 4, 6, 7 and 10 were evaluated for their anti-inflammatory, antioxidant, urease and anti-diabetic effects. Compound 10 showed antioxidant activity, anti-inflammatory effect, urease activity and anti-diabetic activity with IC50 values of 47.3 µM, 33.5 µM, 25.2 µM and 33.9 µM respectively, values that were comparable to the respective positive standards.