Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes.
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ijms-22-07452.pdf
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3.04 MB
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Resource type
Journal article
Date published
July 12, 2021
Abstract
The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and a novel lipid analysis tool, Lipid Traffic Analysis, that uses the temporal distribution of lipids to identify differences in the control of lipid metabolism through a time course. Our results suggest that the start of pregnancy is associated with several changes in lipid metabolism, including fewer variables associated with de novo lipogenesis and fewer PUFA-containing lipids in the circulation. Several of the changes in lipid metabolism in healthy pregnancies were less apparent or occurred later in dams who developed GDM. Some changes in maternal lipid metabolism in the obese-GDM group were so late as to only occur as the control dams’ systems began to switch back towards the non-pregnant state. These results demonstrate that lipid metabolism is modulated in healthy pregnancy and the timing of these changes is altered in GDM pregnancies. These findings raise important questions about how lipid metabolism contributes to changes in metabolism during healthy pregnancies. Furthermore, as alterations in the lipidome are present before the loss of glucose tolerance, they could contribute to the development of GDM mechanistically.
Project(s)
Priority 2: Trait Diversity and Function
Funder
| Funder name | Awards |
Biotechnology and Biological Sciences Research Council, United Kingdom | BB/T014210/1 |
Medical Research Council, United Kingdom | MC_UU_12012/4 |
British Heart Foundation, United Kingdom | RG/17/12/33167 |
Journal title
International Journal of Molecular Sciences
Volume
22
Issue
14
Article number
7452
Publisher
MDPI AG
Place of publication
Basel, Switzerland
eISSN
1422-0067
Date accepted
July 7, 2021
Official URL
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Rights statement
In Copyright
Additional information
IF = 5.542 (2021-2022) ; This article belongs to the Special Issue Molecular Biology of Gestational Diabetes: The Culprit of the Diabetes Pandemic.