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2023
Journal article
Characterization of Terpenoids from the Ambrosia Beetle Symbiont and Laurel Wilt Pathogen Harringtonia lauricola.
Little is known concerning terpenoids produced by members of the fungal order Ophiostomales, with the member Harringtonia lauricola having the unique lifestyle of being a beetle symbiont but potentially devastating tree pathogen. Nine known terpenoids, including six labdane diterpenoids (1–6) and three hopane triterpenes (7–9), were isolated from H. lauricola... -
2023
Journal article
Evidence for Natural Products as Alternative Wound-Healing Therapies.
Chronic, non-healing wounds represent a significant area of unmet medical need and are a growing problem for healthcare systems around the world. They affect the quality of life for patients and are an economic burden, being difficult and time consuming to treat. They are an escalating problem across the developed... -
2021
Journal article
Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis.
This commentary critically examines the modern paradigm of natural volatiles in ‘medical aromatherapy’, first by explaining the semantics of natural volatiles in health, then by addressing chemophenetic challenges to authenticity or reproducibility, and finally by elaborating on pharmacokinetic and pharmacodynamic processes in food, therapy, and disease prophylaxis. Research over the... -
2021
Journal article
Ecdysteroids from the Stem Bark of Vitex doniana Sweet (Lamiaceae; ex. Verbenaceae): A Geographically Variable African Medicinal Species.
Vitex doniana Sweet is an African medicinal species that is prescribed as an aqueous bark extract to be applied topically or orally to achieve anti-infective outcomes. In select regions it is also taken orally as an antimalarial agent. The aim of the current study was to explore the biological properties...Bunu, Musa I. ; Ndinteh, Derek T. ; Macdonald, Jacinta R. ; Langat, Moses K. ; Isyaka, Sani M. …
Ecdysteroid, Malaria, Africa, MIC, Black plum, Antimicrobial, and Vitex doniana
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2022
Journal article
A New Antimicrobial Phenylpropanol from the Leaves of Tabernaemontana inconspicua Stapf. (Apocynaceae) Inhibits Pathogenic Gram-Negative Bacteria.
A chemical investigation of the leaves of Tabernaemontana inconspicua Stapf. led to the isolation of a new phenylpropanol derivative, namely irisdichototin G (1), together with nine known compounds, including one polyol derivative, dambonitol (2); three alkaloids, 10-hydroxycoronaridine (3), voacristine (4) and vobasine (5); two triterpenes lupeol (6), betulinic acid (7)... -
2020
Journal article
Southern Africa as a ‘cradle of incense’ in wider African aromatherapy.
The modern paradigm of aromatherapy is based on in vitro assays of pure volatile organic compounds (as an essential oil), with activity at non-clinically significant concentrations. Yet traditional use of aromatic species did not involve pure essential oils because hydrodistillation was only invented in relatively recent times (estimated 1200 AD)....
