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2022
Journal article
13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.
The biological activities of dehydrocostus lactone and its analogues are suggested to be mediated by the lactone ring and , -methylene- -lactone. However, few studies exist on the structure-activity relationship of 13-amino derivatives of dehydrocostus latone. In this study new 13-amino derivatives of dehydrocostus lactone ( ) were synthesized through...Kemboi, Douglas ; Langat, Moses K. ; Siwe-Noundou, Xavier ; Tshiwawa, Tendamudzimu ; Krause, Rui W. M. …
Protons, Lactones, Cytotoxicity, Breast cancer, Amines, Solubility, Diet, and Toxicity
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2021
Journal article
In vitro cytotoxic effects of chemical constituents of Euphorbia grandicornis Blanc against breast cancer cells.