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Journal article
Mining the chemical diversity of the hemp seed (Cannabis sativa L.) metabolome: discovery of a new molecular family widely distributed across hemp.
Hemp ( L.) is a widely researched industrial crop with a variety of applications in the pharmaceutical, nutraceutical, food, cosmetic, textile, and materials industries. Although many of these applications are related to its chemical composition, the chemical diversity of the hemp metabolome has not been explored in detail and new... -
Journal article
Fundamental Chemistry of Essential Oils and Volatile Organic Compounds, Methods of Analysis and Authentication.
Sadgrove, Nicholas J. ; Padilla-González, Guillermo ; Phumthum, Methee
Learn, Beginners, Volatile organic compounds, Analytical methods, Introduction, Essential oils, and Basic chemistry
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Journal article
Emergence of methicillin resistance predates the clinical use of antibiotics.
The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics . Here we... -
Journal article
Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of Artocarpus heterophyllus Lam.
Colorectal cancer (CRC) represents the third leading cause of death among cancer patients below the age of 50, necessitating improved treatment and prevention initiatives. A crude methanol extract from the wood pulp of was found to be the most bioactive among multiple others, and an enriched extract containing 84% (...Morrison, Isaac J. ; Zhang, Jianan ; Lin, Jingwen ; Murray, JeAnn E. ; Porter, Roy …
Plant sciences, Diseases, Cancer, Molecular medicine, and Biochemistry
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Journal article
Ecdysteroids from the Stem Bark of Vitex doniana Sweet (Lamiaceae; ex. Verbenaceae): A Geographically Variable African Medicinal Species.
Vitex doniana Sweet is an African medicinal species that is prescribed as an aqueous bark extract to be applied topically or orally to achieve anti-infective outcomes. In select regions it is also taken orally as an antimalarial agent. The aim of the current study was to explore the biological properties...Bunu, Musa I. ; Ndinteh, Derek T. ; Macdonald, Jacinta R. ; Langat, Moses K. ; Isyaka, Sani M. …
Ecdysteroid, Malaria, Africa, MIC, Black plum, Antimicrobial, and Vitex doniana
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Journal article
Comparative Metabolomics of Reproductive Organs in the Genus Aesculus (Sapindaceae) Reveals That Immature Fruits Are a Key Organ of Procyanidin Accumulation and Bioactivity.
Fruit from A. hippocastanum L. are used commercially for chronic venous insufficiency (CVI). The isomeric mixture of pentacyclic triterpenoid saponins (β-aescin) exert anti-inflammatory effects. Hence, research has focused on β-aescin, yet the diversity, accumulation, and bioactivity of organ-specific secondary metabolites represent missed pharmacological opportunities. To this end, we applied an... -
Journal article
South Africa’s Best BARK Medicines Prescribed at the Johannesburg Muthi Markets for Skin, Gut, and Lung Infections: MIC’s and Brine Shrimp Lethality.
Indigenous trade of medicinal plants in South Africa is a multi-million-rand industry and is still highly relevant in terms of primary health care. The purpose of this study was to identify today’s most traded medicinal barks, traditionally and contemporaneously used for dermatological, gastrointestinal, and respiratory tract infections; then, to investigate... -
Journal article
Colour of floral styles in the Banksia spinulosa Sm complex (Proteaceae) relates to the anthocyanin and flavonol profile, not soil pH.
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