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Journal article
Three new species segregated from Phebalium squamulosum subsp. squamulosum (Rutaceae) based on morphological and phytochemical data
Phebalium graniticola I.Telford & J.J.Bruhl, P. stellatum I.Telford & J.J.Bruhl and P. sylvaticum I.Telford & J.J.Bruhl are segregated as new species from Phebalium squamulosum Vent. subsp. squamulosum. Essential oil data support the recognition of these species as distinct. Distributions of the new species are mapped, and their habitat and conservation status discussed....Telford, Ian R.H. ; Sadgrove, Nicholas J. ; Bruhl, Jeremy J.
conservation, plant systematics, taxonomy, essential oils, and biodiversity
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Journal article
The Diversity of Volatile Compounds in Australia’s Semi-Desert Genus Eremophila (Scrophulariaceae).
Australia’s endemic desert shrubs are commonly aromatic, with chemically diverse terpenes and phenylpropanoids in their headspace profiles. Species from the genus Eremophila (Scrophulariaceae ex. Myoporaceae) are the most common, with 215 recognised taxa and many more that have not yet been described, widely spread across the arid parts of the... -
Journal article
Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of Artocarpus heterophyllus Lam.
Colorectal cancer (CRC) represents the third leading cause of death among cancer patients below the age of 50, necessitating improved treatment and prevention initiatives. A crude methanol extract from the wood pulp of was found to be the most bioactive among multiple others, and an enriched extract containing 84% (...Morrison, Isaac J. ; Zhang, Jianan ; Lin, Jingwen ; Murray, JeAnn E. ; Porter, Roy …
Plant sciences, Diseases, Cancer, Molecular medicine, and Biochemistry
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Journal article
Volatiles from African species of Croton (Euphorbiaceae), including new diterpenes in essential oil from Croton gratissimus
The chemistry of essential oils from the leaves of three African species of Croton (C. gratissimus, C. pseudopulchellus and C. sylvaticus) is comprehensively characterised. Two new volatile diterpenes were isolated from C. gratissimus and the structures assigned using 1D and 2D NMR. One is a furanyl-halimane methyl ester (1) assigned... -
Journal article
From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products
The new era of multidrug resistance of pathogens against frontline antibiotics has compromised the immense therapeutic gains of the ‘golden age,’ stimulating a resurgence in antimicrobial research focused on antimicrobial and immunomodulatory components of botanical, fungal or microbial origin. While much valuable information has been amassed on the potency of...Sadgrove, Nicholas J. ; Jones, Graham L.
polar head space, rotatable bonds, pharmacodynamics, transdermal penetration, and pharmacokinetics
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Journal article
High-Value Plant Species Used for the Treatment of “Fever” by the Karen Hill Tribe People
The symptom “fever” is generally not itself a terminal condition. However, it does occur with common mild to severe ailments afflicting the world population. Several allopathic medicines are available to attenuate fever by targeting the pathogen or the symptom itself. However, many people in marginal civilizations are obligated to use...Phumthum, Methee ; Sadgrove, Nicholas J.
medicinal plants, antiviral, ethnic group, Thai, infection, antipyretic, antiprotozoal, and ethnobotany
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Journal article
New Labdanes with Antimicrobial and Acaricidal Activity: Terpenes of Callitris and Widdringtonia (Cupressaceae)
In spite of the evidence for antimicrobial and acaricidal effects in ethnobotanical reports of Callitris and Widdringtonia, the diterpene acids from Widdringtonia have never been described and no comparison to the Australian clade sister genus Callitris has been made. The critically endangered South African Clanwilliam cedar, Widdringtonia wallichii (syn. W....Sadgrove, Nicholas J. ; Senbill, Haytham ; Van Wyk, Ben-Erik ; Greatrex, Ben W.
antimicrobial, NMR, Widdringtonia, diterpene, essential oil, Callitris, and cedar
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Journal article
Antimicrobial Isoflavones and Derivatives from Erythrina (Fabaceae): Structure Activity Perspective (Sar & Qsar) on Experimental and Mined Values Against Staphylococcus Aureus
Prenylated (iso)flavonoids, -flavans and pterocarpans from taxa in Erythrina are repeatedly flagged as potent antimicrobial compounds. In the current study, bark from E. lysistemon was extracted and seven isoflavone derivatives were purified: erybraedin A (1), phaseollidin (2), abyssinone V-4’ methyl ether (3), eryzerin C (4), alpumisoflavone (5), cristacarpin (6) and...Sadgrove, Nicholas J. ; Oliveira, Tiago B. ; Khumalo, Gugulethu P. ; Vuuren, Sandy F. van ; van Wyk, Ben-Erik
pterocarpan, MRSA, QSAR; MRSA, prenylated isoflavonoid, and traditional medicine
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Journal article
Feature-Based Molecular Networking to Target the Isolation of New Caffeic Acid Esters from Yacon (Smallanthus sonchifolius, Asteraceae).
Smallanthus sonchifolius (yacon) is an edible tuberous Andean shrub that has been included in the diet of indigenous people since before recorded history. The nutraceutical and medicinal properties of yacon are widely recognized, especially for the improvement of hyperglycemic disorders. However, the chemical diversity of the main bioactive series of...
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