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2019
Journal article
Volatiles from African species of Croton (Euphorbiaceae), including new diterpenes in essential oil from Croton gratissimus
The chemistry of essential oils from the leaves of three African species of Croton (C. gratissimus, C. pseudopulchellus and C. sylvaticus) is comprehensively characterised. Two new volatile diterpenes were isolated from C. gratissimus and the structures assigned using 1D and 2D NMR. One is a furanyl-halimane methyl ester (1) assigned... -
2019
Journal article
From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products
The new era of multidrug resistance of pathogens against frontline antibiotics has compromised the immense therapeutic gains of the ‘golden age,’ stimulating a resurgence in antimicrobial research focused on antimicrobial and immunomodulatory components of botanical, fungal or microbial origin. While much valuable information has been amassed on the potency of...Sadgrove, Nicholas J. ; Jones, Graham L.
polar head space, rotatable bonds, pharmacodynamics, transdermal penetration, and pharmacokinetics
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2020
Journal article
New Labdanes with Antimicrobial and Acaricidal Activity: Terpenes of Callitris and Widdringtonia (Cupressaceae)
In spite of the evidence for antimicrobial and acaricidal effects in ethnobotanical reports of Callitris and Widdringtonia, the diterpene acids from Widdringtonia have never been described and no comparison to the Australian clade sister genus Callitris has been made. The critically endangered South African Clanwilliam cedar, Widdringtonia wallichii (syn. W....Sadgrove, Nicholas J. ; Senbill, Haytham ; Van Wyk, Ben-Erik ; Greatrex, Ben W.
antimicrobial, NMR, Widdringtonia, diterpene, essential oil, Callitris, and cedar
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2020
Journal article
High-Value Plant Species Used for the Treatment of “Fever” by the Karen Hill Tribe People
The symptom “fever” is generally not itself a terminal condition. However, it does occur with common mild to severe ailments afflicting the world population. Several allopathic medicines are available to attenuate fever by targeting the pathogen or the symptom itself. However, many people in marginal civilizations are obligated to use...Phumthum, Methee ; Sadgrove, Nicholas J.
medicinal plants, antiviral, ethnic group, Thai, infection, antipyretic, antiprotozoal, and ethnobotany
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2020
Journal article
Antimicrobial Isoflavones and Derivatives from Erythrina (Fabaceae): Structure Activity Perspective (Sar & Qsar) on Experimental and Mined Values Against Staphylococcus Aureus
Prenylated (iso)flavonoids, -flavans and pterocarpans from taxa in Erythrina are repeatedly flagged as potent antimicrobial compounds. In the current study, bark from E. lysistemon was extracted and seven isoflavone derivatives were purified: erybraedin A (1), phaseollidin (2), abyssinone V-4’ methyl ether (3), eryzerin C (4), alpumisoflavone (5), cristacarpin (6) and...Sadgrove, Nicholas J. ; Oliveira, Tiago B. ; Khumalo, Gugulethu P. ; Vuuren, Sandy F. van ; van Wyk, Ben-Erik
pterocarpan, MRSA, QSAR; MRSA, prenylated isoflavonoid, and traditional medicine
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2019
Journal article
Three new species segregated from Phebalium squamulosum subsp. squamulosum (Rutaceae) based on morphological and phytochemical data
Phebalium graniticola I.Telford & J.J.Bruhl, P. stellatum I.Telford & J.J.Bruhl and P. sylvaticum I.Telford & J.J.Bruhl are segregated as new species from Phebalium squamulosum Vent. subsp. squamulosum. Essential oil data support the recognition of these species as distinct. Distributions of the new species are mapped, and their habitat and conservation status discussed....Telford, Ian R.H. ; Sadgrove, Nicholas J. ; Bruhl, Jeremy J.
conservation, plant systematics, taxonomy, essential oils, and biodiversity
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2020
Journal article
GC–MS ‘chemophenetics’ on Australian pink-flowered Phebalium (Rutaceae) using herbarium leaf material demonstrates phenetic agreement with putative new species.
The aromatic pink-flowered Phebalium complex is comprised by P. nottii Maiden & Betche, P. speciosum I. Telford and the very similar but mostly white-flowered P. woombye (F.M.Bailey) Domin. Phebalium nottii, as currently circumscribed, includes several geographically disjunct populations that have been segregated at the N.C.W. Beadle Herbarium as putatively distinct...Sadgrove, Nicholas J. ; Telford, Ian R.H. ; Padilla-González, Guillermo F. ; Greatrex, Ben W. ; Bruhl, Jeremy J.
Gas chromatography, Chemophenetics, Chemotaxonomy, Volatile terpenes, and Coumarins
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2020
Journal article
Southern Africa as a ‘cradle of incense’ in wider African aromatherapy.
The modern paradigm of aromatherapy is based on in vitro assays of pure volatile organic compounds (as an essential oil), with activity at non-clinically significant concentrations. Yet traditional use of aromatic species did not involve pure essential oils because hydrodistillation was only invented in relatively recent times (estimated 1200 AD).... -
2021
Journal article
Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of Artocarpus heterophyllus Lam.
Colorectal cancer (CRC) represents the third leading cause of death among cancer patients below the age of 50, necessitating improved treatment and prevention initiatives. A crude methanol extract from the wood pulp of was found to be the most bioactive among multiple others, and an enriched extract containing 84% (...Morrison, Isaac J. ; Zhang, Jianan ; Lin, Jingwen ; Murray, JeAnn E. ; Porter, Roy …
Plant sciences, Diseases, Cancer, Molecular medicine, and Biochemistry
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