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2023
Journal article
Cytotoxic Evaluation and Elucidation of Dammarane-Type Triterpenoids Isolated from the Exocarp of Aglaia cucullata (Meliaceae).
Aglaia cucullata is a mangrove plant with a tropical Asian distribution. It is used as traditional medicine for the treatment of diarrhea, inflammation, skin diseases, and heart diseases. Several compounds isolated from A. cucullata have demonstrated cytotoxic activity against various human cancer cells. Cancer therapies such as surgery, chemo-, and...Purnama, ... ; Anjari, Intan Hawina ; Farabi, Kindi ; Runadi, Dudi ; Mayanti, Tri …
Triterpenoid, Meliaceae, Melanoma, Aglaia cucullata, and Cytotoxic
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2023
Journal article
Disrupting iron homeostasis can potentiate colistin activity and overcome colistin resistance mechanisms in Gram-Negative Bacteria.
is a Gram-negative priority pathogen that can readily overcome antibiotic treatment through a range of intrinsic and acquired resistance mechanisms. Treatment of carbapenem-resistant largely relies on the use of colistin in cases where other treatment options have been exhausted. However, the emergence of resistance against this last-line drug has significantly... -
2023
Journal article
Fungal Drug Discovery for Chronic Disease: History, New Discoveries and New Approaches.
Fungal-derived drugs include some of the most important medicines ever discovered, and have proved pivotal in treating chronic diseases. Not only have they saved millions of lives, but they have in some cases changed perceptions of what is medically possible. However, now the low-hanging fruit have been discovered it has...Prescott, Thomas A. K. ; Hill, Rowena ; Mas-Claret, Eduard ; Gaya, Ester ; Burns, Edie
Drugs, Self-resistance, Mechanism of action, Drug distribution, Ecological function, and Fungi
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2023
Journal article
Evidence for Natural Products as Alternative Wound-Healing Therapies.
Chronic, non-healing wounds represent a significant area of unmet medical need and are a growing problem for healthcare systems around the world. They affect the quality of life for patients and are an economic burden, being difficult and time consuming to treat. They are an escalating problem across the developed... -
2013
Journal article
Highly glycosylated flavonols with an O-linked branched pentasaccharide from Iberis saxatilis (Brassicaceae).
Prescott, Thomas A. K. ; Kite, Geoffrey C. ; Porter, Elaine A. ; Veitch, Nigel C.
Iberis saxatilis, Flavonol pentaglycosides, NMR, Cryoprobe, Brassicaceae, MS/MS, 2BC, and Isorhamnetin
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2022
Journal article
A simplified and easy-to-use HIP HOP assay provides insights into chalcone antifungal mechanisms of action.
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2020
Journal article
Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi.
Societal Impact Statement Plants and fungi have provided, or inspired, key pharmaceuticals for global health challenges, including cancer, heart disease, dementia, and malaria, and are valued as traditional medicines worldwide. Global demand for medicinal plants and fungi has threatened certain species, contributing to biodiversity loss and depletion of natural resources...