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2023
Journal article
Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice.
There is growing evidence that poor paternal diet at the time of conception increase the risk of offspring developing a range of non-communicable metabolic diseases, such as obesity, diabetes and cardiovascular disease, in adulthood. We hypothesise that a paternal low protein–high carbohydrate diet perturbs offspring tissue lipid abundance through both...Furse, Samuel ; Morgan, Hannah L. ; Koulman, Albert ; Watkins, Adam J.
Developmental programming, Metabolic disorder, Lipid homeostasis, Semen quality, and Paternal diet
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2022
Journal article
Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.
The underlying mechanisms driving paternally-programmed metabolic disease in offspring remain poorly defined. We fed male C57BL/6 mice either a control normal protein diet (NPD; 18% protein) or an isocaloric low protein diet (LPD; 9% protein) for a minimum of 8 weeks. Using artificial insemination, in combination with vasectomised male mating,...Morgan, Hannah L. ; Furse, Samuel ; Dias, Irundika H. K. ; Shabir, Kiran ; Castellanos, Marcos …
Metabolic homeostasis, Mechanisms of disease, Low protein diet, and Disease model