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Journal article
Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus × paradisi Macfad. (Rutaceae).
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Journal article
13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.
The biological activities of dehydrocostus lactone and its analogues are suggested to be mediated by the lactone ring and , -methylene- -lactone. However, few studies exist on the structure-activity relationship of 13-amino derivatives of dehydrocostus latone. In this study new 13-amino derivatives of dehydrocostus lactone ( ) were synthesized through...Kemboi, Douglas ; Langat, Moses K. ; Siwe-Noundou, Xavier ; Tshiwawa, Tendamudzimu ; Krause, Rui W. M. …
Protons, Lactones, Cytotoxicity, Breast cancer, Amines, Solubility, Diet, and Toxicity
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Journal article
Chemistry, taxonomy and ecology of the potentially chimpanzee-dispersed Vepris teva sp.nov. (Rutaceae) endangered in coastal thicket in the Congo Republic.
Continuing a survey of the chemistry of species of the largely continental African genus , we investigate a species previously referred to as sp. 1 of Congo. From the leaves of sp. 1 we report six compounds. The compounds were three furoquinoline alkaloids, kokusaginine (1), maculine (2), and flindersiamine (3),... -
Journal article
Anti-HIV Ermiasolides from Croton megalocarpus.
In recent years, elucidation of novel anti-HIV bioactive compounds from natural products is gaining importance rapidly, not only from the research and publications, but also from controlled clinical studies. Here we report three new anti-HIV eudesmane-type sesquiterpenes, 5β-Hydroxy-8α-methoxy eudesm-7(11)-en-12,8-olide (1), 5β,8α-Dihydroxy eudesm-7(11)-en-12,8-olide (2) and 5β-Hydroxy-8H-β-eudesm-7(11)-en-12,8-olide (3). These are trivially named...Terefe, Ermias Mergia ; Okalebo, Faith Apolot ; Derese, Solomon ; Langat, Moses K. ; Mas-Claret, Eduard …
Ermiasolides, Cytotoxicity, Anti-HIV activity, HIV-1, and Croton megalocarpus
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Journal article
In vitro antibacterial and cytotoxic effects of Euphorbia grandicornis Blanc chemical constituents.
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Journal article
Host and gut microbiome modulate the antiparasitic activity of nectar metabolites in a bumblebee pollinator.
Koch, Hauke ; Welcome, Vita ; Kendal-Smith, Amy ; Thursfield, Lucy ; Farrell, Iain W. …
Disease, Trypanosomatidae, Host–parasite ecology, Gut microbiota, Bee health, and Phytochemistry
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Journal article
Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of Artocarpus heterophyllus Lam.
Colorectal cancer (CRC) represents the third leading cause of death among cancer patients below the age of 50, necessitating improved treatment and prevention initiatives. A crude methanol extract from the wood pulp of was found to be the most bioactive among multiple others, and an enriched extract containing 84% (...Morrison, Isaac J. ; Zhang, Jianan ; Lin, Jingwen ; Murray, JeAnn E. ; Porter, Roy …
Plant sciences, Diseases, Cancer, Molecular medicine, and Biochemistry
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Journal article
Ecdysteroids from the Stem Bark of Vitex doniana Sweet (Lamiaceae; ex. Verbenaceae): A Geographically Variable African Medicinal Species.
Vitex doniana Sweet is an African medicinal species that is prescribed as an aqueous bark extract to be applied topically or orally to achieve anti-infective outcomes. In select regions it is also taken orally as an antimalarial agent. The aim of the current study was to explore the biological properties...Bunu, Musa I. ; Ndinteh, Derek T. ; Macdonald, Jacinta R. ; Langat, Moses K. ; Isyaka, Sani M. …
Ecdysteroid, Malaria, Africa, MIC, Black plum, Antimicrobial, and Vitex doniana
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Journal article
The effect of isolates from Cassipourea flanaganii (Schinz) alston, a plant used as a skin lightning agent, on melanin production and tyrosinase inhibition
Ethnopharmacological relevance The Zulu and Xhosa people of South Africa use the stem bark of Cassipourea flanaganii as a skin-lightning cosmetic. Aim of the study To isolate and identify compounds responsible for the skin lightning properties from the stem bark of Cassipourea flanaganii and to evaluate their cytotoxicity towards skin...