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Journal article
Cytotoxic ent-abietane diterpenoids, banyangmbolides A-E, from the leaves of Suregada occidentalis.
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Journal article
A new 30-norfriedelane triterpnoid from Caloncoba lophocarpa (Oliv.) Gilg. (Achariaceae).
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Journal article
Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae).
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Journal article
Coumarinolignoid and Indole Alkaloids from the Roots of the Hybrid Plant Citrus x paradisi Macfad. (Rutaceae).
A phytochemical investigation of the roots of Citrus x paradisi Macfad. (Rutaceae) led to the isolation of two new compounds, namely 1-formyl-5-hydroxy-N-methylindolin-1-ium (1) and decyloxycleomiscosin D (2), along with ten known compounds: 1,1-dimethylpyrrolidin-1-ium-2-carboxylate (3), furan-2,3-diol (4), 5-methoxyseselin (5), umbelliferone (6), scopoletin (7), citracridone I (8), citracridone II (9), citracridone III... -
Journal article
Anti-HIV Ermiasolides from Croton megalocarpus.
In recent years, elucidation of novel anti-HIV bioactive compounds from natural products is gaining importance rapidly, not only from the research and publications, but also from controlled clinical studies. Here we report three new anti-HIV eudesmane-type sesquiterpenes, 5β-Hydroxy-8α-methoxy eudesm-7(11)-en-12,8-olide (1), 5β,8α-Dihydroxy eudesm-7(11)-en-12,8-olide (2) and 5β-Hydroxy-8H-β-eudesm-7(11)-en-12,8-olide (3). These are trivially named...Terefe, Ermias Mergia ; Okalebo, Faith Apolot ; Derese, Solomon ; Langat, Moses K. ; Mas-Claret, Eduard …
Ermiasolides, Cytotoxicity, Anti-HIV activity, HIV-1, and Croton megalocarpus
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Journal article
13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.
The biological activities of dehydrocostus lactone and its analogues are suggested to be mediated by the lactone ring and , -methylene- -lactone. However, few studies exist on the structure-activity relationship of 13-amino derivatives of dehydrocostus latone. In this study new 13-amino derivatives of dehydrocostus lactone ( ) were synthesized through...Kemboi, Douglas ; Langat, Moses K. ; Siwe-Noundou, Xavier ; Tshiwawa, Tendamudzimu ; Krause, Rui W. M. …
Protons, Lactones, Cytotoxicity, Breast cancer, Amines, Solubility, Diet, and Toxicity
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Journal article
Chemistry, taxonomy and ecology of the potentially chimpanzee-dispersed Vepris teva sp.nov. (Rutaceae) endangered in coastal thicket in the Congo Republic.
Continuing a survey of the chemistry of species of the largely continental African genus , we investigate a species previously referred to as sp. 1 of Congo. From the leaves of sp. 1 we report six compounds. The compounds were three furoquinoline alkaloids, kokusaginine (1), maculine (2), and flindersiamine (3),... -
Journal article
In vitro antibacterial and cytotoxic effects of Euphorbia grandicornis Blanc chemical constituents.