Search Constraints
Search Results
-
2022
Journal article
13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.
The biological activities of dehydrocostus lactone and its analogues are suggested to be mediated by the lactone ring and , -methylene- -lactone. However, few studies exist on the structure-activity relationship of 13-amino derivatives of dehydrocostus latone. In this study new 13-amino derivatives of dehydrocostus lactone ( ) were synthesized through...Kemboi, Douglas ; Langat, Moses K. ; Siwe-Noundou, Xavier ; Tshiwawa, Tendamudzimu ; Krause, Rui W. M. …
Protons, Lactones, Cytotoxicity, Breast cancer, Amines, Solubility, Diet, and Toxicity
-
2022
Journal article
In vitro antibacterial and cytotoxic effects of Euphorbia grandicornis Blanc chemical constituents.
-
2020
Journal article
A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species.
The genus Euphorbia is one of the largest genera in the spurge family, with diversity in range, distribution, and morphology. The plant species in this genus are widely used in traditional medicine for the treatment of diseases, ranging from respirational infections, body and skin irritations, digestion complaints, inflammatory infections, body...Kemboi, Douglas ; Peter, Xolani ; Langat, Moses ; Tembu, Jacqueline
Anticancer, Phytochemistry, Triterpenoids, Euphorbia, and Ethnomedicinal
-
2021
Journal article
Euphorbia Diterpenes: An Update of Isolation, Structure, Pharmacological Activities and Structure–Activity Relationship.
Euphorbia species have a rich history of ethnomedicinal use and ethnopharmacological applications in drug discovery. This is due to the presence of a wide range of diterpenes exhibiting great structural diversity and pharmacological activities. As a result, Euphorbia diterpenes have remained the focus of drug discovery investigations from natural products....Kemboi, Douglas ; Siwe-Noundou, Xavier ; Krause, Rui W. M. ; Langat, Moses K. ; Tembu, Vuyelwa Jacqueline
Diterpenes, Euphorbia, Pharmacological activity, and Structure–activity relationship