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2023
Journal article
Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice.
There is growing evidence that poor paternal diet at the time of conception increase the risk of offspring developing a range of non-communicable metabolic diseases, such as obesity, diabetes and cardiovascular disease, in adulthood. We hypothesise that a paternal low protein–high carbohydrate diet perturbs offspring tissue lipid abundance through both...Furse, Samuel ; Morgan, Hannah L. ; Koulman, Albert ; Watkins, Adam J.
Developmental programming, Metabolic disorder, Lipid homeostasis, Semen quality, and Paternal diet
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2022
Journal article
The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction.
Mortality in children with severe malnutrition is strongly related to signs of metabolic dysfunction, such as hypoglycemia. Lower circulating tryptophan levels in children with severe malnutrition suggest a possible disturbance in the tryptophan-nicotinamide adenine dinucleotide (TRP-NAD+) pathway and subsequently in NAD+ dependent metabolism regulator sirtuin1 (SIRT1). Here we show that...Hu, Guanlan ; Ling, Catriona ; Chi, Lijun ; Thind, Mehakpreet K. ; Furse, Samuel …
Liver diseases, Energy metabolism, Tryptophan-NAD+ pathway, and Malnutrition
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2022
Journal article
Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.
The underlying mechanisms driving paternally-programmed metabolic disease in offspring remain poorly defined. We fed male C57BL/6 mice either a control normal protein diet (NPD; 18% protein) or an isocaloric low protein diet (LPD; 9% protein) for a minimum of 8 weeks. Using artificial insemination, in combination with vasectomised male mating,...Morgan, Hannah L. ; Furse, Samuel ; Dias, Irundika H. K. ; Shabir, Kiran ; Castellanos, Marcos …
Metabolic homeostasis, Mechanisms of disease, Low protein diet, and Disease model
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2022
Journal article
A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia.
Furse, Samuel ; Fernandez-Twinn, Denise S. ; Beeson, Jessica H. ; Chiarugi, Davide ; Ozanne, Susan E. …
Lipidomics, Mouse models, Type 2 diabetes, and Gestational diabetes
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2021
Journal article
A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies.
Detailed molecular analysis is of increasing importance in research into the regulation of biochemical pathways, organismal growth and disease. Lipidomics in particular is increasingly sought after as it provides insight into molecular species involved in energy storage, signalling and fundamental cellular structures. This has led to the use of a...Furse, Samuel ; Williams, Huw E. L. ; Watkins, Adam J. ; Virtue, Samuel ; Vidal-Puig, Antonio …
Lipidomics, 31P NMR, and Lipid profiling
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2021
Journal article
Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes.
The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and...