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2022
Journal article
Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.
The underlying mechanisms driving paternally-programmed metabolic disease in offspring remain poorly defined. We fed male C57BL/6 mice either a control normal protein diet (NPD; 18% protein) or an isocaloric low protein diet (LPD; 9% protein) for a minimum of 8 weeks. Using artificial insemination, in combination with vasectomised male mating,...Morgan, Hannah L. ; Furse, Samuel ; Dias, Irundika H. K. ; Shabir, Kiran ; Castellanos, Marcos …
Metabolic homeostasis, Mechanisms of disease, Low protein diet, and Disease model