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2022
Journal article
The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction.
Mortality in children with severe malnutrition is strongly related to signs of metabolic dysfunction, such as hypoglycemia. Lower circulating tryptophan levels in children with severe malnutrition suggest a possible disturbance in the tryptophan-nicotinamide adenine dinucleotide (TRP-NAD+) pathway and subsequently in NAD+ dependent metabolism regulator sirtuin1 (SIRT1). Here we show that...Hu, Guanlan ; Ling, Catriona ; Chi, Lijun ; Thind, Mehakpreet K. ; Furse, Samuel …
Liver diseases, Energy metabolism, Tryptophan-NAD+ pathway, and Malnutrition