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2022
Journal article
13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.
The biological activities of dehydrocostus lactone and its analogues are suggested to be mediated by the lactone ring and , -methylene- -lactone. However, few studies exist on the structure-activity relationship of 13-amino derivatives of dehydrocostus latone. In this study new 13-amino derivatives of dehydrocostus lactone ( ) were synthesized through...Kemboi, Douglas ; Langat, Moses K. ; Siwe-Noundou, Xavier ; Tshiwawa, Tendamudzimu ; Krause, Rui W. M. …
Protons, Lactones, Cytotoxicity, Breast cancer, Amines, Solubility, Diet, and Toxicity
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2021
Journal article
Euphorbia Diterpenes: An Update of Isolation, Structure, Pharmacological Activities and Structure–Activity Relationship.
Euphorbia species have a rich history of ethnomedicinal use and ethnopharmacological applications in drug discovery. This is due to the presence of a wide range of diterpenes exhibiting great structural diversity and pharmacological activities. As a result, Euphorbia diterpenes have remained the focus of drug discovery investigations from natural products....Kemboi, Douglas ; Siwe-Noundou, Xavier ; Krause, Rui W. M. ; Langat, Moses K. ; Tembu, Vuyelwa Jacqueline
Diterpenes, Euphorbia, Pharmacological activity, and Structure–activity relationship